Wuxi Guanya Refrigeration Technology co., ltd

What are the decarboxylation reaction conditions and process temperature control?

The decarboxylation of aromatic acids is easier than that of fatty acids. For example, benzoic acid can be decarboxylated by adding a little copper powder as a catalyst in quinoline solution and heating.

When a strong electron-withdrawing group is attached to the α-C of the carboxylic acid, heating can make it decarboxylate more smoothly. For example: when the ortho-diaromatic organic acid is heated, it is easy to remove a carboxyl group, but when the temperature is low, an acid anhydride will be formed. When different polycarboxylic acids are heated, according to the different activities, some are decarboxylated, some are dehydrated, some are decarboxylated and dehydrated again, dehydration above pimelic acid, and general decarboxylation below.

Fatty acid: This reaction is generally not used to prepare alkanes for general fatty acids, especially long-chain fatty acids, because the reaction temperature is too high, the yield is low, and it is not easy to separate. However, if the α-carbon atom of the fatty acid has an electron-withdrawing group such as nitro, halogen, carbonyl, cyano, etc., it makes decarboxylation easy and the yield is high, but their reaction processes are not exactly the same.

The general decarboxylation reaction does not require a special catalyst, but is carried out under the following conditions: (1) heating; (2) alkaline conditions; (3) coexistence of heating and alkaline conditions. The most commonly used decarboxylation method is to heat the sodium salt of carboxylic acid with soda lime (CaO + NaOH) or solid sodium hydroxide, and a decarboxylation reaction occurs, that is, -COONa is replaced by an H atom to generate a carbon atom less than the sodium carboxylic acid salt alkanes.

It can be seen that no matter the decarboxylation reaction of any substance, it is necessary to carry out temperature heating control during the reaction process. LNEYA specializes in the production and development of heating systems, with a temperature control range of 50 degrees to 300 degrees, which is suitable for the needs of pharmaceutical and chemical companies in various process production and experimental use. It can realize high temperature cooling process, directly cooling from high temperature of 300 degrees to 50 degrees. Equipped with a heating and cooling integrated container, the heat exchange area is large, the heating and cooling rate is fast, and the demand for heat transfer oil is small. The entire cycle of the product is closed, there is no oil mist volatilization at high temperature, and the heat transfer oil will not be oxidized and browned; it has the function of correcting the internal cycle temperature probe PT100, and has self-diagnosis and intelligent safety alarm. The equipment is equipped with a variety of safety protection functions such as high-voltage pressure switches, overload relays, and thermal protection devices to ensure the safety of your experiments and production.

Related News
  • 2020 CPhI China The 20th World Pharmaceutical Raw Materials China Exhibition

    2020 CPhI China The 20th World Pharmaceutical Raw Materials China Exhibition

    December 17, 2020December 16-18 Booth number: W5P08 Shanghai New International Expo Center (Pudong)view
  • 483Meet Your Dream Equipment for Distillate CBD Extraction

    483Meet Your Dream Equipment for Distillate CBD Extraction

    February 6, 2021If you need equipment to distill CBD, you need to scrutinize your choices, as the equipment can vary in its features and design. When you use equipment that produces a CBD distillate, you want to seek out a system made by a manufacturer that provides proven and reliable products. You should also work with a business that can train you on the use of the equipment you buy.view
  • Won the second place in the 2022

    Won the second place in the 2022

    December 5, 2022On November 18, 2022, it was sponsored by the Jiangsu Provincial Association for Science and Technology, the Provincial Taiwan Affairs Office, the Provincial Department of Industry and Information Tec...view
  • LNEYA won the title of Jiangsu Provincial Gazelle Enterprise in 2022

    LNEYA won the title of Jiangsu Provincial Gazelle Enterprise in 2022

    January 13, 2023Recently, the Jiangsu Provincial Productivity Promotion Center officially released the evaluation results of the unicorn enterprises and gazelle enterprises in 2022 in Jiangsu and the high-tech zone, ...view
  • Approaching LNEYA 5 Main Products

    Approaching LNEYA 5 Main Products

    January 11, 2018Industrial Chiller:Industrial Chiller varies from dynamic temp. Special Chiller:Special Chiller consist of Multi-reactor chiller (TCU).Environmental Chamber:The test object is connected to a testing adapter. Industrial Freezer:Industrial freezer consist oview
  • The Analysis Of Ultra Low Freezer'S Price

    The Analysis Of Ultra Low Freezer'S Price

    July 4, 2018What are the characteristics and functions of ultra low freezer: 1. Ultra low freezer can prevent the precision of machine equipment from being influenced by the change of oil temperature in the proce...view
Related Products
  • SLJ -110℃~-150℃

    SLJ -110℃~-150℃

    January 11, 2018Temperature ranges from - 5 ~ - 150 ℃, can meet different temperature; Adopt environmental protection refrigerants; Famous brand semi-closed piston compressor, semi-closed bipolar piston compressor, semi-hermetic screw compressor, main brand are BOCK.view
  • Single Fluid Heat Transfer System SR

    Single Fluid Heat Transfer System SR

    April 10, 2018Working temperature range from -25℃to 200℃, other temperature range need to set to the widest temperature range(-50℃to 250℃) Centralized control of 2~20 reactors, each reactor's and jacket temperature can be set independently. One system control multipleview
  • Reactor Temperature System ZLF

    Reactor Temperature System ZLF

    April 10, 2018A set of cooling heat exchanger, heat exchanger, through proportional adjusting valve control cold heat into the heat exchanger, then through the uniform medium input to the reactor jacketed to do heat exchange and temp. Control, system has inside expansiview
  • LT -45℃~30℃

    LT -45℃~30℃

    April 10, 2018Low Temperature Cooling Chiller LT model: LT-5018N,LT-5040N,LT-5062N,LT-5090N,LT-50A1N,LT-50A2N;view
  • TES -45℃~250℃

    TES -45℃~250℃

    February 28, 2019-45℃~+200℃ 2.5kW~25kW ±0.3℃view
  • TES  -85℃~200℃

    TES -85℃~200℃

    February 28, 2019Temperature control range:-85 ° C ~ 200 ° CPower range:2.5kW~25kWTemperature control accuracy:±0.3°CModelTES-8525WTES-8555WTES-85A10WTES-85A15WTES-85A25WTemp. Range-85℃~200℃-85℃~200℃-85℃~200℃-85℃~200℃-85℃~200℃Heating P...view
Contact US
Tel: + 86 18751545184
E-mail: sales@cnzlj.com
Add: No.203, Hongyun Road, Hongshan Street, Optoelectronics Park, Xinwu District, Wuxi City, Jiangsu Province, China
code chat